10月23日【严济慈大讲坛】第二十八讲《 纳米金刚石传感器与细胞功能调控》 [2025-10-22]

报告题目：《纳米金刚石传感器与细胞功能调控》

报  告 人：Prof. Tanja Weil （Max Planck Institute for Polymer Research）

报告时间：2025年10月23日（周四）13:30

报告地点：科大东区师生活动中心五楼报告厅

报告摘要：Nanodiamonds with lattice defects have emerged as photostable  emitters and nanoscale sensors in cell biology. However, nanodiamonds with narrow size distributions and defined lattice defects are still challenging to synthesize. We report the preparation of narrowly dispersed nanodiamonds with different lattice defects and their surface functionalization, which is essential for cellular experiments. Our strategy is to equip nanodiamonds with a functional shell that allows the stimulation and nanoscale sensing of physical parameters and reactive species inside living cells. In living cells, a multitude of biological reactions occur in a concurrent manner, giving rise to an inhomogeneous distribution of different species, temperatures, radicals, and pH at the nanoscale. The local and quantitative detection of these intracellular signals and molecules, including transient reactive structures with limited lifetimes, is of paramount importance. Current methodologies that allow quantification at the nanoscale are frequently constrained to strict conditions such as low temperature or vacuum and are not suitable for living systems. We propose surface-functionalized nanodiamond sensors capable of manipulating and probing critical parameters in situ within the living cell. This approach offers a novel means to elucidate cellular responses to intracellular changes, which could facilitate deeper insights of cell-based diseases and treatments.

报告人简介：Prof. Dr. Tanja Weil has been Director at the Max Planck Institute for Polymer Research (MPIP) since 2017. She also served as Managing Director of MPIP from 2022 to 2024. She studied chemistry (1993-1998) at the TU Braunschweig (Germany) and the University of Bordeaux I (France) and received her PhD from MPIP in 2002 under the supervision of Prof. Klaus Müllen. From 2002 to 2008, she held various leading positions at Merz Pharmaceuticals GmbH, Frankfurt, Germany. In 2008, she accepted a position as Associate Professor at the National University of Singapore. Since 2010, Tanja Weil has been Director of the Institute of Organic Chemistry III at the University of Ulm. She has received competitive grants and awards at both national and international level, including the Karl Ziegler Prize of the German Chemical Society (GDCh), the Otto Hahn Medal of the Max Planck Society, a Synergy Grant of the European Research Council (ERC), the Science Award of the City of Ulm, the Netherlands Supramolecular Chemistry Scholar Award and the Laureate Dr.Manfred Jäger Symposium, Heinrich Heine University Düsseldorf. She is a member of the Senate of the German Research Foundation as well as of the Leibniz Association and serves as Associate Editor for JACS. Her scientific interests are in the field of (bio)materials research and material-cell interactions.

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